SOLTUB.AGRIA.G00000021681

Description : Casein kinase I-like protein

Gene families : OG_02_0001861 (Orthogroups with 8 Potato genotypes) Phylogenetic Tree(s): No tree available for this family

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR Network (HRR 50 & PCC 0.5): SOLTUB.AGRIA.G00000021681
Cluster	HCCA Clusters (HRR 50 & PCC 0.5): Cluster_51

Target	Alias	Description	ECC score	Gene Family Method
SOLTUB.AGRIA.G00000021695	No alias	Casein kinase i family protein	0.17	Orthogroups with 8 Potato genotypes
SOLTUB.AGRIA.G00000021695	No alias	Casein kinase i family protein	0.17	Orthogroups with 8 Potato genotypes
SOLTUB.AGRIA.G00000021695	No alias	Casein kinase i family protein	0.17	Orthogroups with 8 Potato genotypes

Type	GO Term	Name	Evidence	Source
CC	GO:0000139	Golgi membrane	IEA	AHRD
MF	GO:0000166	nucleotide binding	None	Extended
BP	GO:0000226	microtubule cytoskeleton organization	None	Extended
BP	GO:0001558	regulation of cell growth	None	Extended
BP	GO:0001932	regulation of protein phosphorylation	None	Extended
BP	GO:0001934	positive regulation of protein phosphorylation	IEA	AHRD
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004672	protein kinase activity	None	Extended
MF	GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	AHRD
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
MF	GO:0005524	ATP binding	IEA	AHRD
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005654	nucleoplasm	IEA	AHRD
CC	GO:0005813	centrosome	IEA	AHRD
CC	GO:0005815	microtubule organizing center	None	Extended
CC	GO:0005829	cytosol	IEA	AHRD
CC	GO:0005874	microtubule	None	Extended
CC	GO:0005876	spindle microtubule	IEA	AHRD
CC	GO:0005881	cytoplasmic microtubule	None	Extended
CC	GO:0005886	plasma membrane	IEA	AHRD
CC	GO:0005911	cell-cell junction	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	IEA	AHRD
BP	GO:0006468	protein phosphorylation	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006810	transport	None	Extended
BP	GO:0006897	endocytosis	IEA	AHRD
BP	GO:0006901	vesicle coating	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0007010	cytoskeleton organization	None	Extended
BP	GO:0007017	microtubule-based process	None	Extended
BP	GO:0007020	microtubule nucleation	IEA	AHRD
BP	GO:0007030	Golgi organization	IEA	AHRD
BP	GO:0007051	spindle organization	None	Extended
BP	GO:0007610	behavior	None	Extended
BP	GO:0007622	rhythmic behavior	None	Extended
BP	GO:0007623	circadian rhythm	None	Extended
MF	GO:0008092	cytoskeletal protein binding	None	Extended
BP	GO:0008104	protein localization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009266	response to temperature stimulus	None	Extended
BP	GO:0009409	response to cold	IEA	AHRD
CC	GO:0009506	plasmodesma	IEA	AHRD
BP	GO:0009628	response to abiotic stimulus	None	Extended
BP	GO:0009719	response to endogenous stimulus	None	Extended
BP	GO:0009725	response to hormone	None	Extended
BP	GO:0009741	response to brassinosteroid	IEA	AHRD
BP	GO:0009850	auxin metabolic process	IEA	AHRD
BP	GO:0009893	positive regulation of metabolic process	None	Extended
BP	GO:0009894	regulation of catabolic process	None	Extended
BP	GO:0009896	positive regulation of catabolic process	None	Extended
BP	GO:0009966	regulation of signal transduction	None	Extended
BP	GO:0009967	positive regulation of signal transduction	None	Extended
BP	GO:0009968	negative regulation of signal transduction	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010033	response to organic substance	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010562	positive regulation of phosphorus metabolic process	None	Extended
BP	GO:0010604	positive regulation of macromolecule metabolic process	None	Extended
BP	GO:0010646	regulation of cell communication	None	Extended
BP	GO:0010647	positive regulation of cell communication	None	Extended
BP	GO:0010648	negative regulation of cell communication	None	Extended
BP	GO:0010817	regulation of hormone levels	None	Extended
BP	GO:0014070	response to organic cyclic compound	None	Extended
MF	GO:0015631	tubulin binding	IEA	AHRD
CC	GO:0016020	membrane	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
BP	GO:0016050	vesicle organization	None	Extended
BP	GO:0016192	vesicle-mediated transport	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0018105	peptidyl-serine phosphorylation	IEA	AHRD
BP	GO:0018193	peptidyl-amino acid modification	None	Extended
BP	GO:0018209	peptidyl-serine modification	None	Extended
BP	GO:0019220	regulation of phosphate metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0022402	cell cycle process	None	Extended
BP	GO:0022603	regulation of anatomical structure morphogenesis	None	Extended
BP	GO:0022604	regulation of cell morphogenesis	None	Extended
BP	GO:0022607	cellular component assembly	None	Extended
BP	GO:0023051	regulation of signaling	None	Extended
BP	GO:0023056	positive regulation of signaling	None	Extended
BP	GO:0023057	negative regulation of signaling	None	Extended
BP	GO:0030030	cell projection organization	None	Extended
BP	GO:0030031	cell projection assembly	None	Extended
CC	GO:0030054	cell junction	None	Extended
BP	GO:0030111	regulation of Wnt signaling pathway	None	Extended
BP	GO:0030162	regulation of proteolysis	None	Extended
BP	GO:0030177	positive regulation of Wnt signaling pathway	None	Extended
BP	GO:0030178	negative regulation of Wnt signaling pathway	IEA	AHRD
CC	GO:0030426	growth cone	IEA	AHRD
CC	GO:0030427	site of polarized growth	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
BP	GO:0030865	cortical cytoskeleton organization	None	Extended
CC	GO:0031090	organelle membrane	None	Extended
BP	GO:0031122	cytoplasmic microtubule organization	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031325	positive regulation of cellular metabolic process	None	Extended
BP	GO:0031329	regulation of cellular catabolic process	None	Extended
BP	GO:0031331	positive regulation of cellular catabolic process	None	Extended
BP	GO:0031399	regulation of protein modification process	None	Extended
BP	GO:0031401	positive regulation of protein modification process	None	Extended
BP	GO:0032091	negative regulation of protein binding	IEA	AHRD
BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	None	Extended
BP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA	AHRD
BP	GO:0032501	multicellular organismal process	None	Extended
BP	GO:0032502	developmental process	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0032922	circadian regulation of gene expression	IEA	AHRD
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
CC	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	IEA	AHRD
BP	GO:0033365	protein localization to organelle	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0033993	response to lipid	None	Extended
BP	GO:0034067	protein localization to Golgi apparatus	IEA	AHRD
BP	GO:0034248	regulation of cellular amide metabolic process	None	Extended
BP	GO:0034250	positive regulation of cellular amide metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
CC	GO:0036064	ciliary basal body	IEA	AHRD
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0036211	protein modification process	None	Extended
BP	GO:0040008	regulation of growth	None	Extended
BP	GO:0042176	regulation of protein catabolic process	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042325	regulation of phosphorylation	None	Extended
BP	GO:0042327	positive regulation of phosphorylation	None	Extended
BP	GO:0042445	hormone metabolic process	None	Extended
BP	GO:0042752	regulation of circadian rhythm	IEA	AHRD
CC	GO:0042995	cell projection	None	Extended
CC	GO:0043025	neuronal cell body	IEA	AHRD
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043393	regulation of protein binding	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043622	cortical microtubule organization	IEA	AHRD
BP	GO:0043933	protein-containing complex organization	None	Extended
BP	GO:0044092	negative regulation of molecular function	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044297	cell body	None	Extended
BP	GO:0044380	protein localization to cytoskeleton	None	Extended
BP	GO:0044782	cilium organization	None	Extended
BP	GO:0045595	regulation of cell differentiation	None	Extended
BP	GO:0045597	positive regulation of cell differentiation	None	Extended
BP	GO:0045664	regulation of neuron differentiation	None	Extended
BP	GO:0045666	positive regulation of neuron differentiation	None	Extended
BP	GO:0045732	positive regulation of protein catabolic process	None	Extended
BP	GO:0045862	positive regulation of proteolysis	None	Extended
BP	GO:0045937	positive regulation of phosphate metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046777	protein autophosphorylation	IEA	AHRD
BP	GO:0048208	COPII vesicle coating	IEA	AHRD
BP	GO:0048364	root development	IEA	AHRD
CC	GO:0048471	perinuclear region of cytoplasm	IEA	AHRD
BP	GO:0048511	rhythmic process	None	Extended
BP	GO:0048512	circadian behavior	IEA	AHRD
BP	GO:0048518	positive regulation of biological process	None	Extended
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048522	positive regulation of cellular process	None	Extended
BP	GO:0048523	negative regulation of cellular process	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0048584	positive regulation of response to stimulus	None	Extended
BP	GO:0048585	negative regulation of response to stimulus	None	Extended
BP	GO:0048638	regulation of developmental growth	None	Extended
BP	GO:0048856	anatomical structure development	None	Extended
MF	GO:0050321	tau-protein kinase activity	IEA	AHRD
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050793	regulation of developmental process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051094	positive regulation of developmental process	None	Extended
BP	GO:0051098	regulation of binding	None	Extended
BP	GO:0051100	negative regulation of binding	None	Extended
BP	GO:0051128	regulation of cellular component organization	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051173	positive regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051174	regulation of phosphorus metabolic process	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051225	spindle assembly	IEA	AHRD
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051246	regulation of protein metabolic process	None	Extended
BP	GO:0051247	positive regulation of protein metabolic process	None	Extended
BP	GO:0051510	regulation of unidimensional cell growth	IEA	AHRD
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
CC	GO:0055028	cortical microtubule	IEA	AHRD
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0060271	cilium assembly	None	Extended
BP	GO:0060828	regulation of canonical Wnt signaling pathway	None	Extended
BP	GO:0061136	regulation of proteasomal protein catabolic process	None	Extended
BP	GO:0061512	protein localization to cilium	IEA	AHRD
BP	GO:0065003	protein-containing complex assembly	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065008	regulation of biological quality	None	Extended
BP	GO:0065009	regulation of molecular function	None	Extended
CC	GO:0070161	anchoring junction	None	Extended
BP	GO:0070727	cellular macromolecule localization	None	Extended
BP	GO:0070848	response to growth factor	None	Extended
BP	GO:0070887	cellular response to chemical stimulus	None	Extended
BP	GO:0070925	organelle assembly	None	Extended
BP	GO:0071310	cellular response to organic substance	None	Extended
BP	GO:0071363	cellular response to growth factor stimulus	None	Extended
BP	GO:0071495	cellular response to endogenous stimulus	None	Extended
BP	GO:0071539	protein localization to centrosome	IEA	AHRD
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0072698	protein localization to microtubule cytoskeleton	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA	AHRD
BP	GO:0090304	nucleic acid metabolic process	None	Extended
CC	GO:0090395	plant cell papilla	None	Extended
CC	GO:0090397	stigma papilla	IEA	AHRD
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
BP	GO:0097435	supramolecular fiber organization	None	Extended
CC	GO:0098588	bounding membrane of organelle	None	Extended
CC	GO:0099080	supramolecular complex	None	Extended
CC	GO:0099081	supramolecular polymer	None	Extended
BP	GO:0099402	plant organ development	None	Extended
CC	GO:0099512	supramolecular fiber	None	Extended
CC	GO:0099513	polymeric cytoskeletal fiber	None	Extended
MF	GO:0106310	protein serine kinase activity	IEA	AHRD
CC	GO:0110165	cellular anatomical entity	None	Extended
BP	GO:0120031	plasma membrane bounded cell projection assembly	None	Extended
BP	GO:0120036	plasma membrane bounded cell projection organization	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:0140694	non-membrane-bounded organelle assembly	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901700	response to oxygen-containing compound	None	Extended
BP	GO:1901800	positive regulation of proteasomal protein catabolic process	None	Extended
BP	GO:1902003	regulation of amyloid-beta formation	None	Extended
BP	GO:1902004	positive regulation of amyloid-beta formation	IEA	AHRD
BP	GO:1902991	regulation of amyloid precursor protein catabolic process	None	Extended
BP	GO:1902993	positive regulation of amyloid precursor protein catabolic process	None	Extended
BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	None	Extended
BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	None	Extended
BP	GO:1904338	regulation of dopaminergic neuron differentiation	None	Extended
BP	GO:1904340	positive regulation of dopaminergic neuron differentiation	None	Extended
BP	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	None	Extended
BP	GO:1904958	positive regulation of midbrain dopaminergic neuron differentiation	None	Extended
BP	GO:1905424	regulation of Wnt-mediated midbrain dopaminergic neuron differentiation	None	Extended
BP	GO:1905426	positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation	IEA	AHRD
BP	GO:1905508	protein localization to microtubule organizing center	None	Extended
BP	GO:1905515	non-motile cilium assembly	IEA	AHRD
BP	GO:1990089	response to nerve growth factor	None	Extended
BP	GO:1990090	cellular response to nerve growth factor stimulus	IEA	AHRD
CC	GO:1990904	ribonucleoprotein complex	IEA	AHRD
BP	GO:2000050	regulation of non-canonical Wnt signaling pathway	None	Extended
BP	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	IEA	AHRD
BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	None	Extended
BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0005516	calmodulin binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0005643	nuclear pore	IEP	Predict GO terms from Neighborhoods
CC	GO:0005856	cytoskeleton	IEP	Predict GO terms from Neighborhoods
BP	GO:0006405	RNA export from nucleus	IEP	Predict GO terms from Neighborhoods
BP	GO:0006406	mRNA export from nucleus	IEP	Predict GO terms from Neighborhoods
BP	GO:0006913	nucleocytoplasmic transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0007346	regulation of mitotic cell cycle	IEP	Predict GO terms from Neighborhoods
BP	GO:0009909	regulation of flower development	IEP	Predict GO terms from Neighborhoods
BP	GO:0009910	negative regulation of flower development	IEP	Predict GO terms from Neighborhoods
BP	GO:0010564	regulation of cell cycle process	IEP	Predict GO terms from Neighborhoods
BP	GO:0010965	regulation of mitotic sister chromatid separation	IEP	Predict GO terms from Neighborhoods
CC	GO:0015630	microtubule cytoskeleton	IEP	Predict GO terms from Neighborhoods
BP	GO:0015931	nucleobase-containing compound transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0016973	poly(A)+ mRNA export from nucleus	IEP	Predict GO terms from Neighborhoods
BP	GO:0031400	negative regulation of protein modification process	IEP	Predict GO terms from Neighborhoods
BP	GO:0032386	regulation of intracellular transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032388	positive regulation of intracellular transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032880	regulation of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0033044	regulation of chromosome organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0033157	regulation of intracellular protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0033233	regulation of protein sumoylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0033234	negative regulation of protein sumoylation	IEP	Predict GO terms from Neighborhoods
CC	GO:0034399	nuclear periphery	IEP	Predict GO terms from Neighborhoods
BP	GO:0046822	regulation of nucleocytoplasmic transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0048437	floral organ development	IEP	Predict GO terms from Neighborhoods
BP	GO:0048443	stamen development	IEP	Predict GO terms from Neighborhoods
BP	GO:0048581	negative regulation of post-embryonic development	IEP	Predict GO terms from Neighborhoods
BP	GO:0048827	phyllome development	IEP	Predict GO terms from Neighborhoods
BP	GO:0048831	regulation of shoot system development	IEP	Predict GO terms from Neighborhoods
BP	GO:0050657	nucleic acid transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0050658	RNA transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051028	mRNA transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051050	positive regulation of transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051168	nuclear export	IEP	Predict GO terms from Neighborhoods
BP	GO:0051169	nuclear transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051222	positive regulation of protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051223	regulation of protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051236	establishment of RNA localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051983	regulation of chromosome segregation	IEP	Predict GO terms from Neighborhoods
BP	GO:0060341	regulation of cellular localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0060968	obsolete regulation of gene silencing	IEP	Predict GO terms from Neighborhoods
BP	GO:0070201	regulation of establishment of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0090316	positive regulation of intracellular protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	IEP	Predict GO terms from Neighborhoods
BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	IEP	Predict GO terms from Neighborhoods
BP	GO:1903829	positive regulation of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:1904951	positive regulation of establishment of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:1905818	regulation of chromosome separation	IEP	Predict GO terms from Neighborhoods
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:2000242	negative regulation of reproductive process	IEP	Predict GO terms from Neighborhoods

InterPro domains	Description	Start	Stop
IPR000719	Prot_kinase_dom	9	205
IPR011009	Kinase-like_dom_sf	4	284

External Links

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SOLTUB.AGRIA.G00000021681

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation