SOLTUB.AGRIA.G00000035892

Description : Transmembrane and coiled-coil domains protein

Gene families : OG_02_0006919 (Orthogroups with 8 Potato genotypes) Phylogenetic Tree(s): No tree available for this family

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR Network (HRR 50 & PCC 0.5): SOLTUB.AGRIA.G00000035892
Cluster	HCCA Clusters (HRR 50 & PCC 0.5): Cluster_217

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005216	ion channel activity	None	Extended
MF	GO:0005261	cation channel activity	None	Extended
MF	GO:0005262	calcium channel activity	IEA	AHRD
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IEA	AHRD
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006810	transport	None	Extended
BP	GO:0006811	ion transport	None	Extended
BP	GO:0006812	cation transport	None	Extended
BP	GO:0006816	calcium ion transport	None	Extended
BP	GO:0006873	cellular ion homeostasis	None	Extended
BP	GO:0006874	cellular calcium ion homeostasis	None	Extended
BP	GO:0006875	cellular metal ion homeostasis	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006983	ER overload response	IEA	AHRD
BP	GO:0006984	ER-nucleus signaling pathway	None	Extended
BP	GO:0007165	signal transduction	None	Extended
BP	GO:0008150	biological_process	None	Extended
MF	GO:0008324	cation transmembrane transporter activity	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0015075	ion transmembrane transporter activity	None	Extended
MF	GO:0015085	calcium ion transmembrane transporter activity	None	Extended
MF	GO:0015267	channel activity	None	Extended
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	None	Extended
CC	GO:0016021	integral component of membrane	None	Extended
BP	GO:0019725	cellular homeostasis	None	Extended
MF	GO:0022803	passive transmembrane transporter activity	None	Extended
MF	GO:0022857	transmembrane transporter activity	None	Extended
MF	GO:0022890	inorganic cation transmembrane transporter activity	None	Extended
BP	GO:0030001	metal ion transport	None	Extended
BP	GO:0030003	cellular cation homeostasis	None	Extended
CC	GO:0030176	integral component of endoplasmic reticulum membrane	IEA	AHRD
CC	GO:0031224	intrinsic component of membrane	None	Extended
CC	GO:0031227	intrinsic component of endoplasmic reticulum membrane	None	Extended
CC	GO:0031300	intrinsic component of organelle membrane	None	Extended
CC	GO:0031301	integral component of organelle membrane	None	Extended
BP	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IEA	AHRD
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034220	ion transmembrane transport	None	Extended
BP	GO:0034976	response to endoplasmic reticulum stress	None	Extended
BP	GO:0042592	homeostatic process	None	Extended
MF	GO:0043021	ribonucleoprotein complex binding	None	Extended
MF	GO:0043022	ribosome binding	IEA	AHRD
MF	GO:0044877	protein-containing complex binding	None	Extended
MF	GO:0046873	metal ion transmembrane transporter activity	None	Extended
BP	GO:0048878	chemical homeostasis	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050801	ion homeostasis	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0055065	metal ion homeostasis	None	Extended
BP	GO:0055074	calcium ion homeostasis	None	Extended
BP	GO:0055080	cation homeostasis	None	Extended
BP	GO:0055082	cellular chemical homeostasis	None	Extended
BP	GO:0055085	transmembrane transport	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065008	regulation of biological quality	None	Extended
BP	GO:0070588	calcium ion transmembrane transport	IEA	AHRD
BP	GO:0071216	cellular response to biotic stimulus	None	Extended
BP	GO:0072503	cellular divalent inorganic cation homeostasis	None	Extended
BP	GO:0072507	divalent inorganic cation homeostasis	None	Extended
BP	GO:0098655	cation transmembrane transport	None	Extended
BP	GO:0098660	inorganic ion transmembrane transport	None	Extended
BP	GO:0098662	inorganic cation transmembrane transport	None	Extended
BP	GO:0098771	inorganic ion homeostasis	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000152	nuclear ubiquitin ligase complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain	IEP	Predict GO terms from Neighborhoods
BP	GO:0000266	mitochondrial fission	IEP	Predict GO terms from Neighborhoods
BP	GO:0000338	protein deneddylation	IEP	Predict GO terms from Neighborhoods
CC	GO:0000421	autophagosome membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0000919	cell plate assembly	IEP	Predict GO terms from Neighborhoods
BP	GO:0002443	leukocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002444	myeloid leukocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002446	neutrophil mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002573	myeloid leukocyte differentiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0003400	regulation of COPII vesicle coating	IEP	Predict GO terms from Neighborhoods
MF	GO:0003924	GTPase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0003925	G protein activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004576	oligosaccharyl transferase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0005525	GTP binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0005680	anaphase-promoting complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0005770	late endosome	IEP	Predict GO terms from Neighborhoods
CC	GO:0005771	multivesicular body	IEP	Predict GO terms from Neighborhoods
CC	GO:0005787	signal peptidase complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0005789	endoplasmic reticulum membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0005828	kinetochore microtubule	IEP	Predict GO terms from Neighborhoods
BP	GO:0006413	translational initiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0006465	signal peptide processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0006487	protein N-linked glycosylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0006508	proteolysis	IEP	Predict GO terms from Neighborhoods
BP	GO:0006605	protein targeting	IEP	Predict GO terms from Neighborhoods
BP	GO:0006886	intracellular protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006998	nuclear envelope organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0007006	mitochondrial membrane organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0007029	endoplasmic reticulum organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0007080	mitotic metaphase plate congression	IEP	Predict GO terms from Neighborhoods
BP	GO:0008104	protein localization	IEP	Predict GO terms from Neighborhoods
CC	GO:0008180	COP9 signalosome	IEP	Predict GO terms from Neighborhoods
MF	GO:0008233	peptidase activity	IEP	Predict GO terms from Neighborhoods
CC	GO:0008250	oligosaccharyltransferase complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0009920	cell plate formation involved in plant-type cell wall biogenesis	IEP	Predict GO terms from Neighborhoods
BP	GO:0010387	COP9 signalosome assembly	IEP	Predict GO terms from Neighborhoods
BP	GO:0010634	positive regulation of epithelial cell migration	IEP	Predict GO terms from Neighborhoods
BP	GO:0010796	regulation of multivesicular body size	IEP	Predict GO terms from Neighborhoods
BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IEP	Predict GO terms from Neighborhoods
BP	GO:0015031	protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0015918	sterol transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0016192	vesicle-mediated transport	IEP	Predict GO terms from Neighborhoods
MF	GO:0016462	pyrophosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0016477	cell migration	IEP	Predict GO terms from Neighborhoods
BP	GO:0016485	protein processing	IEP	Predict GO terms from Neighborhoods
MF	GO:0016787	hydrolase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predict GO terms from Neighborhoods
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predict GO terms from Neighborhoods
MF	GO:0017111	ribonucleoside triphosphate phosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0018196	peptidyl-asparagine modification	IEP	Predict GO terms from Neighborhoods
BP	GO:0018279	protein N-linked glycosylation via asparagine	IEP	Predict GO terms from Neighborhoods
MF	GO:0019001	guanyl nucleotide binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0019082	viral protein processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0019221	cytokine-mediated signaling pathway	IEP	Predict GO terms from Neighborhoods
CC	GO:0030117	membrane coat	IEP	Predict GO terms from Neighborhoods
CC	GO:0030120	vesicle coat	IEP	Predict GO terms from Neighborhoods
CC	GO:0030127	COPII vesicle coat	IEP	Predict GO terms from Neighborhoods
BP	GO:0030223	neutrophil differentiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0030301	cholesterol transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0030516	regulation of axon extension	IEP	Predict GO terms from Neighborhoods
BP	GO:0030718	germ-line stem cell population maintenance	IEP	Predict GO terms from Neighborhoods
BP	GO:0030851	granulocyte differentiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0030953	astral microtubule organization	IEP	Predict GO terms from Neighborhoods
CC	GO:0031090	organelle membrane	IEP	Predict GO terms from Neighborhoods
MF	GO:0031489	myosin V binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0031901	early endosome membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0032154	cleavage furrow	IEP	Predict GO terms from Neighborhoods
MF	GO:0032266	phosphatidylinositol-3-phosphate binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0032365	intracellular lipid transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032366	intracellular sterol transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032367	intracellular cholesterol transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032400	melanosome localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0032401	establishment of melanosome localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0032402	melanosome transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0032456	endocytic recycling	IEP	Predict GO terms from Neighborhoods
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0032588	trans-Golgi network membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0032880	regulation of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0032944	regulation of mononuclear cell proliferation	IEP	Predict GO terms from Neighborhoods
CC	GO:0032991	protein-containing complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0033036	macromolecule localization	IEP	Predict GO terms from Neighborhoods
CC	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	IEP	Predict GO terms from Neighborhoods
CC	GO:0033179	proton-transporting V-type ATPase, V0 domain	IEP	Predict GO terms from Neighborhoods
BP	GO:0033365	protein localization to organelle	IEP	Predict GO terms from Neighborhoods
BP	GO:0034394	protein localization to cell surface	IEP	Predict GO terms from Neighborhoods
CC	GO:0034451	centriolar satellite	IEP	Predict GO terms from Neighborhoods
BP	GO:0035418	protein localization to synapse	IEP	Predict GO terms from Neighborhoods
BP	GO:0036099	female germ-line stem cell population maintenance	IEP	Predict GO terms from Neighborhoods
BP	GO:0036257	multivesicular body organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0036258	multivesicular body assembly	IEP	Predict GO terms from Neighborhoods
BP	GO:0038158	granulocyte colony-stimulating factor signaling pathway	IEP	Predict GO terms from Neighborhoods
MF	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0044183	protein folding chaperone	IEP	Predict GO terms from Neighborhoods
CC	GO:0044232	organelle membrane contact site	IEP	Predict GO terms from Neighborhoods
CC	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0045047	protein targeting to ER	IEP	Predict GO terms from Neighborhoods
BP	GO:0045048	protein insertion into ER membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0045056	transcytosis	IEP	Predict GO terms from Neighborhoods
BP	GO:0045184	establishment of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0045428	regulation of nitric oxide biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0045444	fat cell differentiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0045773	positive regulation of axon extension	IEP	Predict GO terms from Neighborhoods
BP	GO:0046907	intracellular transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0048138	germ-line cyst encapsulation	IEP	Predict GO terms from Neighborhoods
BP	GO:0048140	male germ-line cyst encapsulation	IEP	Predict GO terms from Neighborhoods
BP	GO:0048168	regulation of neuronal synaptic plasticity	IEP	Predict GO terms from Neighborhoods
BP	GO:0048169	regulation of long-term neuronal synaptic plasticity	IEP	Predict GO terms from Neighborhoods
BP	GO:0048870	cell motility	IEP	Predict GO terms from Neighborhoods
MF	GO:0050355	inorganic triphosphate phosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0050764	regulation of phagocytosis	IEP	Predict GO terms from Neighborhoods
BP	GO:0050770	regulation of axonogenesis	IEP	Predict GO terms from Neighborhoods
BP	GO:0050772	positive regulation of axonogenesis	IEP	Predict GO terms from Neighborhoods
BP	GO:0050900	leukocyte migration	IEP	Predict GO terms from Neighborhoods
BP	GO:0051036	regulation of endosome size	IEP	Predict GO terms from Neighborhoods
BP	GO:0051205	protein insertion into membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0051223	regulation of protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051303	establishment of chromosome localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051310	metaphase plate congression	IEP	Predict GO terms from Neighborhoods
BP	GO:0051604	protein maturation	IEP	Predict GO terms from Neighborhoods
BP	GO:0051641	cellular localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051668	localization within membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0051875	pigment granule localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051904	pigment granule transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051905	establishment of pigment granule localization	IEP	Predict GO terms from Neighborhoods
CC	GO:0055037	recycling endosome	IEP	Predict GO terms from Neighborhoods
CC	GO:0055038	recycling endosome membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0060627	regulation of vesicle-mediated transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0060628	regulation of ER to Golgi vesicle-mediated transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0061387	regulation of extent of cell growth	IEP	Predict GO terms from Neighborhoods
BP	GO:0061951	establishment of protein localization to plasma membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0062237	protein localization to postsynapse	IEP	Predict GO terms from Neighborhoods
CC	GO:0070062	extracellular exosome	IEP	Predict GO terms from Neighborhoods
MF	GO:0070122	obsolete isopeptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0070201	regulation of establishment of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0070663	regulation of leukocyte proliferation	IEP	Predict GO terms from Neighborhoods
BP	GO:0070727	cellular macromolecule localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0070861	regulation of protein exit from endoplasmic reticulum	IEP	Predict GO terms from Neighborhoods
BP	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	IEP	Predict GO terms from Neighborhoods
CC	GO:0070971	endoplasmic reticulum exit site	IEP	Predict GO terms from Neighborhoods
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Predict GO terms from Neighborhoods
BP	GO:0071702	organic substance transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0071705	nitrogen compound transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0072583	clathrin-dependent endocytosis	IEP	Predict GO terms from Neighborhoods
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predict GO terms from Neighborhoods
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Predict GO terms from Neighborhoods
BP	GO:0072657	protein localization to membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0080164	regulation of nitric oxide metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0090113	regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis	IEP	Predict GO terms from Neighborhoods
BP	GO:0090150	establishment of protein localization to membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0090307	mitotic spindle assembly	IEP	Predict GO terms from Neighborhoods
BP	GO:0097120	receptor localization to synapse	IEP	Predict GO terms from Neighborhoods
BP	GO:0097242	amyloid-beta clearance	IEP	Predict GO terms from Neighborhoods
BP	GO:0097494	regulation of vesicle size	IEP	Predict GO terms from Neighborhoods
BP	GO:0097529	myeloid leukocyte migration	IEP	Predict GO terms from Neighborhoods
BP	GO:0097530	granulocyte migration	IEP	Predict GO terms from Neighborhoods
CC	GO:0098685	Schaffer collateral - CA1 synapse	IEP	Predict GO terms from Neighborhoods
CC	GO:0098796	membrane protein complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0098837	postsynaptic recycling endosome	IEP	Predict GO terms from Neighborhoods
CC	GO:0098845	postsynaptic endosome	IEP	Predict GO terms from Neighborhoods
BP	GO:0098877	neurotransmitter receptor transport to plasma membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IEP	Predict GO terms from Neighborhoods
BP	GO:0099637	neurotransmitter receptor transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0099638	endosome to plasma membrane protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0140534	endoplasmic reticulum protein-containing complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0150093	amyloid-beta clearance by transcytosis	IEP	Predict GO terms from Neighborhoods
BP	GO:1902414	protein localization to cell junction	IEP	Predict GO terms from Neighborhoods
CC	GO:1902494	catalytic complex	IEP	Predict GO terms from Neighborhoods
BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	IEP	Predict GO terms from Neighborhoods
BP	GO:1903078	positive regulation of protein localization to plasma membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:1903525	regulation of membrane tubulation	IEP	Predict GO terms from Neighborhoods
BP	GO:1903527	positive regulation of membrane tubulation	IEP	Predict GO terms from Neighborhoods
BP	GO:1903539	protein localization to postsynaptic membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:1903540	establishment of protein localization to postsynaptic membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:1903729	regulation of plasma membrane organization	IEP	Predict GO terms from Neighborhoods
BP	GO:1903829	positive regulation of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:1904377	positive regulation of protein localization to cell periphery	IEP	Predict GO terms from Neighborhoods
CC	GO:1905368	peptidase complex	IEP	Predict GO terms from Neighborhoods
BP	GO:1905477	positive regulation of protein localization to membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:1990182	exosomal secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:1990266	neutrophil migration	IEP	Predict GO terms from Neighborhoods
BP	GO:1990641	response to iron ion starvation	IEP	Predict GO terms from Neighborhoods

InterPro domains	Description	Start	Stop
IPR002809	EMC3/TMCO1	16	175

External Links

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SOLTUB.AGRIA.G00000035892

Expression Profile

Co-expression Networks

Functional Annotation