"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]
There are 551 sequences with this label.
| Name | Species | % in cluster | p-value | corrected p-value | action |
|---|---|---|---|---|---|
| Cluster_19 | Solanum tuberosum Agria | 1.9 % | 0.00076 | 0.019808 |