GO:0034335: DNA negative supercoiling activity (Molecular function)

"Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase]


There are 62 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_130 Solanum tuberosum Agria 1.12 % 0.004549 0.032419
Sequences (62) (download table)

InterPro Domains

GO Terms

Family Terms