GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


There are 751 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_37 Solanum tuberosum Agria 1.79 % 0.000642 0.004198
Cluster_226 Solanum tuberosum Agria 2.46 % 0.001282 0.013719
Cluster_173 Solanum tuberosum Agria 2.78 % 0.000902 0.010037
Sequences (751) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms