1. Home
  2. GO
  3. GO:0140223

GO:0140223: general transcription initiation factor activity (Molecular function)

"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]


There are 522 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_780 Solanum tuberosum Agria 50.0 % 0.002812 0.020112
Cluster_36 Solanum tuberosum Agria 1.73 % 0.00032 0.003184
Cluster_134 Solanum tuberosum Agria 2.67 % 0.005051 0.030322
Cluster_632 Solanum tuberosum Agria 50.0 % 0.002812 0.016835
Sequences (522) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms