GO:0140467: integrated stress response signaling (Biological process)

"The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]


There are 169 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_119 Solanum tuberosum Agria 1.18 % 0.012978 0.03982
Sequences (169) (download table)

InterPro Domains

GO Terms

Family Terms