"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
There are 719 sequences with this label.
| Name | Species | % in cluster | p-value | corrected p-value | action |
|---|---|---|---|---|---|
| Cluster_83 | Solanum tuberosum Agria | 1.89 % | 0.005628 | 0.02414 | |
| Cluster_22 | Solanum tuberosum Agria | 2.46 % | 0.002683 | 0.034579 | |
| Cluster_818 | Solanum tuberosum Agria | 33.33 % | 0.006739 | 0.023292 | |
| Cluster_36 | Solanum tuberosum Agria | 2.16 % | 0.000181 | 0.001979 | |
| Cluster_197 | Solanum tuberosum Agria | 1.47 % | 0.011106 | 0.047976 | |
| Cluster_119 | Solanum tuberosum Agria | 2.35 % | 0.01585 | 0.046188 | |
| Cluster_81 | Solanum tuberosum Agria | 2.88 % | 0.001704 | 0.010085 | |
| Cluster_746 | Solanum tuberosum Agria | 100.0 % | 5e-06 | 3.7e-05 | |
| Cluster_339 | Solanum tuberosum Agria | 22.22 % | 0.000179 | 0.00438 | |
| Cluster_325 | Solanum tuberosum Agria | 33.33 % | 0.006739 | 0.021081 |