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GO:0140358: P-type transmembrane transporter activity (Molecular function)

"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]


There are 658 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_157 Solanum tuberosum Agria 3.03 % 0.003394 0.026991
Cluster_169 Solanum tuberosum Agria 1.93 % 0.000157 0.003072
Cluster_31 Solanum tuberosum Agria 2.94 % 0.003598 0.015667
Cluster_76 Solanum tuberosum Agria 2.74 % 0.004134 0.030573
Sequences (658) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms