SOLTUB.AGRIA.G00000040441

Description : Shaggy-related protein kinase epsilon

Gene families : OG_02_0004446 (Orthogroups with 8 Potato genotypes) Phylogenetic Tree(s): No tree available for this family

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR Network (HRR 50 & PCC 0.5): SOLTUB.AGRIA.G00000040441
Cluster	HCCA Clusters (HRR 50 & PCC 0.5): Cluster_249

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
BP	GO:0000320	re-entry into mitotic cell cycle	IEA	AHRD
BP	GO:0000768	syncytium formation by plasma membrane fusion	None	Extended
BP	GO:0001505	regulation of neurotransmitter levels	None	Extended
BP	GO:0001558	regulation of cell growth	None	Extended
BP	GO:0001775	cell activation	None	Extended
BP	GO:0001837	epithelial to mesenchymal transition	IEA	AHRD
BP	GO:0001932	regulation of protein phosphorylation	None	Extended
BP	GO:0001933	negative regulation of protein phosphorylation	None	Extended
BP	GO:0001934	positive regulation of protein phosphorylation	None	Extended
BP	GO:0001952	regulation of cell-matrix adhesion	None	Extended
BP	GO:0001954	positive regulation of cell-matrix adhesion	IEA	AHRD
MF	GO:0002020	protease binding	IEA	AHRD
MF	GO:0002039	p53 binding	IEA	AHRD
BP	GO:0002682	regulation of immune system process	None	Extended
BP	GO:0002684	positive regulation of immune system process	None	Extended
BP	GO:0002761	regulation of myeloid leukocyte differentiation	None	Extended
BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004672	protein kinase activity	None	Extended
MF	GO:0005102	signaling receptor binding	None	Extended
MF	GO:0005178	integrin binding	IEA	AHRD
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
MF	GO:0005524	ATP binding	IEA	AHRD
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005654	nucleoplasm	IEA	AHRD
CC	GO:0005737	cytoplasm	None	Extended
CC	GO:0005739	mitochondrion	IEA	AHRD
CC	GO:0005813	centrosome	IEA	AHRD
CC	GO:0005815	microtubule organizing center	None	Extended
CC	GO:0005829	cytosol	IEA	AHRD
CC	GO:0005874	microtubule	IEA	AHRD
CC	GO:0005886	plasma membrane	IEA	AHRD
CC	GO:0005938	cell cortex	IEA	AHRD
BP	GO:0005975	carbohydrate metabolic process	None	Extended
BP	GO:0005976	polysaccharide metabolic process	None	Extended
BP	GO:0005977	glycogen metabolic process	IEA	AHRD
BP	GO:0006073	cellular glucan metabolic process	None	Extended
BP	GO:0006091	generation of precursor metabolites and energy	None	Extended
BP	GO:0006112	energy reserve metabolic process	None	Extended
BP	GO:0006349	regulation of gene expression by genomic imprinting	IEA	AHRD
BP	GO:0006355	regulation of DNA-templated transcription	None	Extended
BP	GO:0006357	regulation of transcription by RNA polymerase II	None	Extended
BP	GO:0006468	protein phosphorylation	None	Extended
BP	GO:0006469	negative regulation of protein kinase activity	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006915	apoptotic process	None	Extended
BP	GO:0006949	syncytium formation	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006970	response to osmotic stress	None	Extended
BP	GO:0006972	hyperosmotic response	None	Extended
BP	GO:0006983	ER overload response	IEA	AHRD
BP	GO:0006984	ER-nucleus signaling pathway	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0007005	mitochondrion organization	None	Extended
BP	GO:0007006	mitochondrial membrane organization	None	Extended
BP	GO:0007163	establishment or maintenance of cell polarity	None	Extended
BP	GO:0007165	signal transduction	None	Extended
BP	GO:0007166	cell surface receptor signaling pathway	None	Extended
BP	GO:0007167	enzyme-linked receptor protein signaling pathway	None	Extended
BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	None	Extended
BP	GO:0007520	myoblast fusion	IEA	AHRD
MF	GO:0008013	beta-catenin binding	IEA	AHRD
MF	GO:0008092	cytoskeletal protein binding	None	Extended
BP	GO:0008104	protein localization	None	Extended
MF	GO:0008134	transcription factor binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008219	cell death	None	Extended
BP	GO:0008284	positive regulation of cell population proliferation	None	Extended
BP	GO:0008286	insulin receptor signaling pathway	IEA	AHRD
BP	GO:0008582	regulation of synaptic assembly at neuromuscular junction	None	Extended
BP	GO:0009593	detection of chemical stimulus	None	Extended
BP	GO:0009605	response to external stimulus	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
BP	GO:0009612	response to mechanical stimulus	None	Extended
BP	GO:0009628	response to abiotic stimulus	None	Extended
BP	GO:0009651	response to salt stress	None	Extended
BP	GO:0009653	anatomical structure morphogenesis	None	Extended
BP	GO:0009719	response to endogenous stimulus	None	Extended
BP	GO:0009720	detection of hormone stimulus	None	Extended
BP	GO:0009725	response to hormone	None	Extended
BP	GO:0009726	detection of endogenous stimulus	None	Extended
BP	GO:0009729	detection of brassinosteroid stimulus	IEA	AHRD
BP	GO:0009733	response to auxin	IEA	AHRD
BP	GO:0009741	response to brassinosteroid	None	Extended
BP	GO:0009825	multidimensional cell growth	IEA	AHRD
BP	GO:0009887	animal organ morphogenesis	IEA	AHRD
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009890	negative regulation of biosynthetic process	None	Extended
BP	GO:0009891	positive regulation of biosynthetic process	None	Extended
BP	GO:0009892	negative regulation of metabolic process	None	Extended
BP	GO:0009893	positive regulation of metabolic process	None	Extended
BP	GO:0009894	regulation of catabolic process	None	Extended
BP	GO:0009896	positive regulation of catabolic process	None	Extended
BP	GO:0009933	meristem structural organization	IEA	AHRD
BP	GO:0009965	leaf morphogenesis	IEA	AHRD
BP	GO:0009966	regulation of signal transduction	None	Extended
BP	GO:0009967	positive regulation of signal transduction	None	Extended
BP	GO:0009968	negative regulation of signal transduction	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010033	response to organic substance	None	Extended
BP	GO:0010035	response to inorganic substance	None	Extended
BP	GO:0010038	response to metal ion	None	Extended
BP	GO:0010043	response to zinc ion	IEA	AHRD
BP	GO:0010053	root epidermal cell differentiation	None	Extended
BP	GO:0010243	response to organonitrogen compound	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010506	regulation of autophagy	None	Extended
BP	GO:0010508	positive regulation of autophagy	IEA	AHRD
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0010557	positive regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0010562	positive regulation of phosphorus metabolic process	None	Extended
BP	GO:0010563	negative regulation of phosphorus metabolic process	None	Extended
BP	GO:0010604	positive regulation of macromolecule metabolic process	None	Extended
BP	GO:0010605	negative regulation of macromolecule metabolic process	None	Extended
BP	GO:0010611	regulation of cardiac muscle hypertrophy	None	Extended
BP	GO:0010614	negative regulation of cardiac muscle hypertrophy	IEA	AHRD
BP	GO:0010628	positive regulation of gene expression	IEA	AHRD
BP	GO:0010638	positive regulation of organelle organization	None	Extended
BP	GO:0010646	regulation of cell communication	None	Extended
BP	GO:0010647	positive regulation of cell communication	None	Extended
BP	GO:0010648	negative regulation of cell communication	None	Extended
BP	GO:0010656	negative regulation of muscle cell apoptotic process	None	Extended
BP	GO:0010660	regulation of muscle cell apoptotic process	None	Extended
BP	GO:0010720	positive regulation of cell development	None	Extended
BP	GO:0010721	negative regulation of cell development	None	Extended
BP	GO:0010799	regulation of peptidyl-threonine phosphorylation	None	Extended
BP	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IEA	AHRD
BP	GO:0010810	regulation of cell-substrate adhesion	None	Extended
BP	GO:0010811	positive regulation of cell-substrate adhesion	None	Extended
BP	GO:0010821	regulation of mitochondrion organization	None	Extended
BP	GO:0010822	positive regulation of mitochondrion organization	None	Extended
BP	GO:0010918	positive regulation of mitochondrial membrane potential	IEA	AHRD
BP	GO:0010941	regulation of cell death	None	Extended
BP	GO:0010942	positive regulation of cell death	None	Extended
BP	GO:0010975	regulation of neuron projection development	None	Extended
BP	GO:0010977	negative regulation of neuron projection development	None	Extended
BP	GO:0012501	programmed cell death	None	Extended
BP	GO:0014041	regulation of neuron maturation	None	Extended
BP	GO:0014043	negative regulation of neuron maturation	IEA	AHRD
CC	GO:0014069	postsynaptic density	IEA	AHRD
BP	GO:0014070	response to organic cyclic compound	None	Extended
BP	GO:0014741	negative regulation of muscle hypertrophy	None	Extended
BP	GO:0014743	regulation of muscle hypertrophy	None	Extended
BP	GO:0015980	energy derivation by oxidation of organic compounds	None	Extended
CC	GO:0016020	membrane	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
BP	GO:0016049	cell growth	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0017157	regulation of exocytosis	None	Extended
BP	GO:0018105	peptidyl-serine phosphorylation	IEA	AHRD
BP	GO:0018193	peptidyl-amino acid modification	None	Extended
BP	GO:0018209	peptidyl-serine modification	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019220	regulation of phosphate metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0019899	enzyme binding	None	Extended
MF	GO:0019900	kinase binding	None	Extended
MF	GO:0019901	protein kinase binding	None	Extended
BP	GO:0021700	developmental maturation	None	Extended
BP	GO:0021766	hippocampus development	IEA	AHRD
BP	GO:0022402	cell cycle process	None	Extended
BP	GO:0022603	regulation of anatomical structure morphogenesis	None	Extended
BP	GO:0023051	regulation of signaling	None	Extended
BP	GO:0023056	positive regulation of signaling	None	Extended
BP	GO:0023057	negative regulation of signaling	None	Extended
BP	GO:0030010	establishment of cell polarity	IEA	AHRD
BP	GO:0030011	maintenance of cell polarity	IEA	AHRD
BP	GO:0030030	cell projection organization	None	Extended
CC	GO:0030054	cell junction	None	Extended
BP	GO:0030111	regulation of Wnt signaling pathway	None	Extended
BP	GO:0030154	cell differentiation	None	Extended
BP	GO:0030155	regulation of cell adhesion	None	Extended
BP	GO:0030162	regulation of proteolysis	None	Extended
BP	GO:0030178	negative regulation of Wnt signaling pathway	None	Extended
BP	GO:0030307	positive regulation of cell growth	None	Extended
BP	GO:0030334	regulation of cell migration	None	Extended
BP	GO:0030336	negative regulation of cell migration	None	Extended
CC	GO:0030426	growth cone	IEA	AHRD
CC	GO:0030427	site of polarized growth	None	Extended
BP	GO:0030516	regulation of axon extension	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
CC	GO:0030877	beta-catenin destruction complex	IEA	AHRD
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031324	negative regulation of cellular metabolic process	None	Extended
BP	GO:0031325	positive regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0031327	negative regulation of cellular biosynthetic process	None	Extended
BP	GO:0031328	positive regulation of cellular biosynthetic process	None	Extended
BP	GO:0031329	regulation of cellular catabolic process	None	Extended
BP	GO:0031331	positive regulation of cellular catabolic process	None	Extended
BP	GO:0031333	negative regulation of protein-containing complex assembly	IEA	AHRD
BP	GO:0031334	positive regulation of protein-containing complex assembly	IEA	AHRD
BP	GO:0031344	regulation of cell projection organization	None	Extended
BP	GO:0031345	negative regulation of cell projection organization	None	Extended
BP	GO:0031346	positive regulation of cell projection organization	None	Extended
BP	GO:0031399	regulation of protein modification process	None	Extended
BP	GO:0031400	negative regulation of protein modification process	None	Extended
BP	GO:0031401	positive regulation of protein modification process	None	Extended
MF	GO:0031625	ubiquitin protein ligase binding	IEA	AHRD
BP	GO:0031644	regulation of nervous system process	None	Extended
BP	GO:0032006	regulation of TOR signaling	None	Extended
BP	GO:0032007	negative regulation of TOR signaling	IEA	AHRD
BP	GO:0032091	negative regulation of protein binding	IEA	AHRD
BP	GO:0032092	positive regulation of protein binding	IEA	AHRD
BP	GO:0032386	regulation of intracellular transport	None	Extended
BP	GO:0032388	positive regulation of intracellular transport	None	Extended
BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	None	Extended
BP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA	AHRD
BP	GO:0032501	multicellular organismal process	None	Extended
BP	GO:0032502	developmental process	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0032768	regulation of monooxygenase activity	None	Extended
BP	GO:0032769	negative regulation of monooxygenase activity	None	Extended
BP	GO:0032879	regulation of localization	None	Extended
BP	GO:0032880	regulation of protein localization	None	Extended
BP	GO:0032886	regulation of microtubule-based process	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
BP	GO:0033043	regulation of organelle organization	None	Extended
BP	GO:0033157	regulation of intracellular protein transport	None	Extended
BP	GO:0033365	protein localization to organelle	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0033673	negative regulation of kinase activity	None	Extended
BP	GO:0033688	regulation of osteoblast proliferation	None	Extended
BP	GO:0033690	positive regulation of osteoblast proliferation	IEA	AHRD
BP	GO:0033993	response to lipid	None	Extended
BP	GO:0034097	response to cytokine	None	Extended
MF	GO:0034236	protein kinase A catalytic subunit binding	IEA	AHRD
BP	GO:0034391	regulation of smooth muscle cell apoptotic process	None	Extended
BP	GO:0034392	negative regulation of smooth muscle cell apoptotic process	IEA	AHRD
MF	GO:0034452	dynactin binding	IEA	AHRD
BP	GO:0034976	response to endoplasmic reticulum stress	None	Extended
MF	GO:0035254	glutamate receptor binding	None	Extended
MF	GO:0035255	ionotropic glutamate receptor binding	IEA	AHRD
BP	GO:0035372	protein localization to microtubule	IEA	AHRD
BP	GO:0035556	intracellular signal transduction	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
BP	GO:0035728	response to hepatocyte growth factor	None	Extended
BP	GO:0035729	cellular response to hepatocyte growth factor stimulus	IEA	AHRD
BP	GO:0035733	hepatic stellate cell activation	IEA	AHRD
BP	GO:0035794	positive regulation of mitochondrial membrane permeability	None	Extended
BP	GO:0036015	response to interleukin-3	None	Extended
BP	GO:0036016	cellular response to interleukin-3	IEA	AHRD
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0036211	protein modification process	None	Extended
BP	GO:0038034	signal transduction in absence of ligand	None	Extended
BP	GO:0040007	growth	None	Extended
BP	GO:0040008	regulation of growth	None	Extended
BP	GO:0040012	regulation of locomotion	None	Extended
BP	GO:0040013	negative regulation of locomotion	None	Extended
BP	GO:0040029	epigenetic regulation of gene expression	None	Extended
BP	GO:0042127	regulation of cell population proliferation	None	Extended
BP	GO:0042176	regulation of protein catabolic process	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042325	regulation of phosphorylation	None	Extended
BP	GO:0042326	negative regulation of phosphorylation	None	Extended
BP	GO:0042327	positive regulation of phosphorylation	None	Extended
BP	GO:0042391	regulation of membrane potential	None	Extended
BP	GO:0042538	hyperosmotic salinity response	IEA	AHRD
BP	GO:0042752	regulation of circadian rhythm	IEA	AHRD
MF	GO:0042802	identical protein binding	IEA	AHRD
BP	GO:0042981	regulation of apoptotic process	None	Extended
CC	GO:0042995	cell projection	None	Extended
CC	GO:0043005	neuron projection	None	Extended
CC	GO:0043025	neuronal cell body	IEA	AHRD
BP	GO:0043065	positive regulation of apoptotic process	None	Extended
BP	GO:0043066	negative regulation of apoptotic process	None	Extended
BP	GO:0043067	regulation of programmed cell death	None	Extended
BP	GO:0043068	positive regulation of programmed cell death	None	Extended
BP	GO:0043069	negative regulation of programmed cell death	None	Extended
BP	GO:0043085	positive regulation of catalytic activity	None	Extended
BP	GO:0043086	negative regulation of catalytic activity	None	Extended
BP	GO:0043087	regulation of GTPase activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043197	dendritic spine	IEA	AHRD
CC	GO:0043198	dendritic shaft	IEA	AHRD
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043254	regulation of protein-containing complex assembly	None	Extended
BP	GO:0043393	regulation of protein binding	None	Extended
BP	GO:0043405	regulation of MAP kinase activity	None	Extended
BP	GO:0043407	negative regulation of MAP kinase activity	IEA	AHRD
BP	GO:0043408	regulation of MAPK cascade	None	Extended
BP	GO:0043409	negative regulation of MAPK cascade	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043502	regulation of muscle adaptation	None	Extended
BP	GO:0043523	regulation of neuron apoptotic process	None	Extended
BP	GO:0043525	positive regulation of neuron apoptotic process	IEA	AHRD
BP	GO:0043547	positive regulation of GTPase activity	IEA	AHRD
BP	GO:0043549	regulation of kinase activity	None	Extended
BP	GO:0044026	DNA hypermethylation	None	Extended
BP	GO:0044027	hypermethylation of CpG island	IEA	AHRD
BP	GO:0044030	regulation of DNA methylation	None	Extended
BP	GO:0044042	glucan metabolic process	None	Extended
BP	GO:0044057	regulation of system process	None	Extended
BP	GO:0044087	regulation of cellular component biogenesis	None	Extended
BP	GO:0044089	positive regulation of cellular component biogenesis	None	Extended
BP	GO:0044092	negative regulation of molecular function	None	Extended
BP	GO:0044093	positive regulation of molecular function	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044262	cellular carbohydrate metabolic process	None	Extended
BP	GO:0044264	cellular polysaccharide metabolic process	None	Extended
CC	GO:0044297	cell body	None	Extended
CC	GO:0044309	neuron spine	None	Extended
BP	GO:0044380	protein localization to cytoskeleton	None	Extended
MF	GO:0044389	ubiquitin-like protein ligase binding	None	Extended
MF	GO:0044877	protein-containing complex binding	None	Extended
CC	GO:0045121	membrane raft	IEA	AHRD
CC	GO:0045202	synapse	None	Extended
BP	GO:0045444	fat cell differentiation	IEA	AHRD
BP	GO:0045595	regulation of cell differentiation	None	Extended
BP	GO:0045596	negative regulation of cell differentiation	None	Extended
BP	GO:0045597	positive regulation of cell differentiation	None	Extended
BP	GO:0045637	regulation of myeloid cell differentiation	None	Extended
BP	GO:0045639	positive regulation of myeloid cell differentiation	None	Extended
BP	GO:0045664	regulation of neuron differentiation	None	Extended
BP	GO:0045665	negative regulation of neuron differentiation	None	Extended
BP	GO:0045667	regulation of osteoblast differentiation	IEA	AHRD
BP	GO:0045670	regulation of osteoclast differentiation	None	Extended
BP	GO:0045672	positive regulation of osteoclast differentiation	IEA	AHRD
BP	GO:0045732	positive regulation of protein catabolic process	None	Extended
BP	GO:0045773	positive regulation of axon extension	IEA	AHRD
BP	GO:0045785	positive regulation of cell adhesion	None	Extended
BP	GO:0045838	positive regulation of membrane potential	None	Extended
BP	GO:0045859	regulation of protein kinase activity	None	Extended
BP	GO:0045862	positive regulation of proteolysis	None	Extended
BP	GO:0045886	negative regulation of synaptic assembly at neuromuscular junction	IEA	AHRD
BP	GO:0045887	positive regulation of synaptic assembly at neuromuscular junction	IEA	AHRD
BP	GO:0045892	negative regulation of DNA-templated transcription	IEA	AHRD
BP	GO:0045893	positive regulation of DNA-templated transcription	None	Extended
BP	GO:0045926	negative regulation of growth	None	Extended
BP	GO:0045927	positive regulation of growth	None	Extended
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0045936	negative regulation of phosphate metabolic process	None	Extended
BP	GO:0045937	positive regulation of phosphate metabolic process	None	Extended
BP	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	AHRD
BP	GO:0046777	protein autophosphorylation	IEA	AHRD
BP	GO:0046822	regulation of nucleocytoplasmic transport	None	Extended
BP	GO:0046824	positive regulation of nucleocytoplasmic transport	None	Extended
BP	GO:0046825	regulation of protein export from nucleus	None	Extended
BP	GO:0046827	positive regulation of protein export from nucleus	IEA	AHRD
BP	GO:0046849	bone remodeling	IEA	AHRD
BP	GO:0046902	regulation of mitochondrial membrane permeability	None	Extended
BP	GO:0046928	regulation of neurotransmitter secretion	None	Extended
BP	GO:0047484	regulation of response to osmotic stress	None	Extended
MF	GO:0048156	tau protein binding	IEA	AHRD
BP	GO:0048167	regulation of synaptic plasticity	None	Extended
BP	GO:0048168	regulation of neuronal synaptic plasticity	IEA	AHRD
BP	GO:0048469	cell maturation	None	Extended
CC	GO:0048471	perinuclear region of cytoplasm	IEA	AHRD
BP	GO:0048518	positive regulation of biological process	None	Extended
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048522	positive regulation of cellular process	None	Extended
BP	GO:0048523	negative regulation of cellular process	None	Extended
BP	GO:0048532	anatomical structure arrangement	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0048584	positive regulation of response to stimulus	None	Extended
BP	GO:0048585	negative regulation of response to stimulus	None	Extended
BP	GO:0048588	developmental cell growth	None	Extended
BP	GO:0048589	developmental growth	None	Extended
BP	GO:0048638	regulation of developmental growth	None	Extended
BP	GO:0048639	positive regulation of developmental growth	None	Extended
BP	GO:0048640	negative regulation of developmental growth	None	Extended
BP	GO:0048646	anatomical structure formation involved in morphogenesis	None	Extended
BP	GO:0048660	regulation of smooth muscle cell proliferation	None	Extended
BP	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA	AHRD
BP	GO:0048762	mesenchymal cell differentiation	None	Extended
BP	GO:0048764	trichoblast maturation	None	Extended
BP	GO:0048765	root hair cell differentiation	IEA	AHRD
BP	GO:0048771	tissue remodeling	None	Extended
BP	GO:0048814	regulation of dendrite morphogenesis	None	Extended
BP	GO:0048856	anatomical structure development	None	Extended
BP	GO:0048869	cellular developmental process	None	Extended
MF	GO:0050321	tau-protein kinase activity	IEA	AHRD
BP	GO:0050767	regulation of neurogenesis	None	Extended
BP	GO:0050768	negative regulation of neurogenesis	None	Extended
BP	GO:0050769	positive regulation of neurogenesis	None	Extended
BP	GO:0050770	regulation of axonogenesis	None	Extended
BP	GO:0050772	positive regulation of axonogenesis	None	Extended
BP	GO:0050773	regulation of dendrite development	None	Extended
BP	GO:0050774	negative regulation of dendrite morphogenesis	IEA	AHRD
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050790	regulation of catalytic activity	None	Extended
BP	GO:0050793	regulation of developmental process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050804	modulation of chemical synaptic transmission	None	Extended
BP	GO:0050807	regulation of synapse organization	None	Extended
MF	GO:0050839	cell adhesion molecule binding	None	Extended
BP	GO:0050848	regulation of calcium-mediated signaling	None	Extended
BP	GO:0050849	negative regulation of calcium-mediated signaling	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0050999	regulation of nitric-oxide synthase activity	None	Extended
BP	GO:0051001	negative regulation of nitric-oxide synthase activity	IEA	AHRD
MF	GO:0051018	protein kinase A binding	None	Extended
BP	GO:0051046	regulation of secretion	None	Extended
BP	GO:0051049	regulation of transport	None	Extended
BP	GO:0051050	positive regulation of transport	None	Extended
BP	GO:0051052	regulation of DNA metabolic process	None	Extended
BP	GO:0051054	positive regulation of DNA metabolic process	None	Extended
MF	GO:0051059	NF-kappaB binding	IEA	AHRD
BP	GO:0051093	negative regulation of developmental process	None	Extended
BP	GO:0051094	positive regulation of developmental process	None	Extended
BP	GO:0051098	regulation of binding	None	Extended
BP	GO:0051099	positive regulation of binding	None	Extended
BP	GO:0051100	negative regulation of binding	None	Extended
BP	GO:0051128	regulation of cellular component organization	None	Extended
BP	GO:0051129	negative regulation of cellular component organization	None	Extended
BP	GO:0051130	positive regulation of cellular component organization	None	Extended
BP	GO:0051147	regulation of muscle cell differentiation	None	Extended
BP	GO:0051149	positive regulation of muscle cell differentiation	None	Extended
BP	GO:0051153	regulation of striated muscle cell differentiation	None	Extended
BP	GO:0051155	positive regulation of striated muscle cell differentiation	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051173	positive regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051174	regulation of phosphorus metabolic process	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051222	positive regulation of protein transport	None	Extended
BP	GO:0051223	regulation of protein transport	None	Extended
BP	GO:0051239	regulation of multicellular organismal process	None	Extended
BP	GO:0051240	positive regulation of multicellular organismal process	None	Extended
BP	GO:0051241	negative regulation of multicellular organismal process	None	Extended
BP	GO:0051246	regulation of protein metabolic process	None	Extended
BP	GO:0051247	positive regulation of protein metabolic process	None	Extended
BP	GO:0051248	negative regulation of protein metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0051253	negative regulation of RNA metabolic process	None	Extended
BP	GO:0051254	positive regulation of RNA metabolic process	None	Extended
BP	GO:0051336	regulation of hydrolase activity	None	Extended
BP	GO:0051338	regulation of transferase activity	None	Extended
BP	GO:0051341	regulation of oxidoreductase activity	None	Extended
BP	GO:0051345	positive regulation of hydrolase activity	None	Extended
BP	GO:0051348	negative regulation of transferase activity	None	Extended
BP	GO:0051354	negative regulation of oxidoreductase activity	None	Extended
BP	GO:0051493	regulation of cytoskeleton organization	None	Extended
BP	GO:0051588	regulation of neurotransmitter transport	None	Extended
BP	GO:0051606	detection of stimulus	None	Extended
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0051881	regulation of mitochondrial membrane potential	None	Extended
BP	GO:0051960	regulation of nervous system development	None	Extended
BP	GO:0051961	negative regulation of nervous system development	None	Extended
BP	GO:0051962	positive regulation of nervous system development	None	Extended
BP	GO:0051963	regulation of synapse assembly	None	Extended
BP	GO:0051964	negative regulation of synapse assembly	None	Extended
BP	GO:0051965	positive regulation of synapse assembly	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0060284	regulation of cell development	None	Extended
BP	GO:0060341	regulation of cellular localization	None	Extended
BP	GO:0060548	negative regulation of cell death	None	Extended
BP	GO:0060627	regulation of vesicle-mediated transport	None	Extended
BP	GO:0060828	regulation of canonical Wnt signaling pathway	None	Extended
BP	GO:0061024	membrane organization	None	Extended
BP	GO:0061049	cell growth involved in cardiac muscle cell development	IEA	AHRD
BP	GO:0061136	regulation of proteasomal protein catabolic process	None	Extended
BP	GO:0061387	regulation of extent of cell growth	None	Extended
MF	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	None	Extended
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065008	regulation of biological quality	None	Extended
BP	GO:0065009	regulation of molecular function	None	Extended
BP	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA	AHRD
BP	GO:0070201	regulation of establishment of protein localization	None	Extended
BP	GO:0070507	regulation of microtubule cytoskeleton organization	None	Extended
BP	GO:0070663	regulation of leukocyte proliferation	None	Extended
BP	GO:0070665	positive regulation of leukocyte proliferation	None	Extended
BP	GO:0070727	cellular macromolecule localization	None	Extended
MF	GO:0070840	dynein complex binding	IEA	AHRD
BP	GO:0070848	response to growth factor	None	Extended
BP	GO:0070884	regulation of calcineurin-NFAT signaling cascade	None	Extended
BP	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IEA	AHRD
BP	GO:0070887	cellular response to chemical stimulus	None	Extended
BP	GO:0071109	superior temporal gyrus development	IEA	AHRD
BP	GO:0071214	cellular response to abiotic stimulus	None	Extended
BP	GO:0071216	cellular response to biotic stimulus	None	Extended
BP	GO:0071260	cellular response to mechanical stimulus	IEA	AHRD
BP	GO:0071310	cellular response to organic substance	None	Extended
BP	GO:0071345	cellular response to cytokine stimulus	None	Extended
BP	GO:0071363	cellular response to growth factor stimulus	None	Extended
BP	GO:0071417	cellular response to organonitrogen compound	None	Extended
BP	GO:0071495	cellular response to endogenous stimulus	None	Extended
BP	GO:0071496	cellular response to external stimulus	None	Extended
BP	GO:0071695	anatomical structure maturation	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0071900	regulation of protein serine/threonine kinase activity	None	Extended
BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	None	Extended
BP	GO:0072537	fibroblast activation	None	Extended
BP	GO:0072698	protein localization to microtubule cytoskeleton	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0080134	regulation of response to stress	None	Extended
BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	IEA	AHRD
BP	GO:0090257	regulation of muscle system process	None	Extended
BP	GO:0090289	regulation of osteoclast proliferation	None	Extended
BP	GO:0090290	positive regulation of osteoclast proliferation	IEA	AHRD
BP	GO:0090316	positive regulation of intracellular protein transport	None	Extended
BP	GO:0090559	regulation of membrane permeability	None	Extended
BP	GO:0090627	plant epidermal cell differentiation	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:0097190	apoptotic signaling pathway	None	Extended
BP	GO:0097191	extrinsic apoptotic signaling pathway	None	Extended
BP	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IEA	AHRD
BP	GO:0097193	intrinsic apoptotic signaling pathway	None	Extended
BP	GO:0097284	hepatocyte apoptotic process	IEA	AHRD
MF	GO:0097367	carbohydrate derivative binding	None	Extended
CC	GO:0098685	Schaffer collateral - CA1 synapse	IEA	AHRD
BP	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA	AHRD
CC	GO:0098794	postsynapse	None	Extended
BP	GO:0098815	modulation of excitatory postsynaptic potential	None	Extended
CC	GO:0098857	membrane microdomain	None	Extended
CC	GO:0098978	glutamatergic synapse	IEA	AHRD
CC	GO:0099080	supramolecular complex	None	Extended
CC	GO:0099081	supramolecular polymer	None	Extended
BP	GO:0099159	regulation of modification of postsynaptic structure	IEA	AHRD
BP	GO:0099177	regulation of trans-synaptic signaling	None	Extended
CC	GO:0099512	supramolecular fiber	None	Extended
CC	GO:0099513	polymeric cytoskeletal fiber	None	Extended
CC	GO:0099572	postsynaptic specialization	None	Extended
BP	GO:0104004	cellular response to environmental stimulus	None	Extended
BP	GO:0106027	neuron projection organization	IEA	AHRD
BP	GO:0106056	regulation of calcineurin-mediated signaling	None	Extended
BP	GO:0106057	negative regulation of calcineurin-mediated signaling	None	Extended
MF	GO:0106310	protein serine kinase activity	IEA	AHRD
CC	GO:0110165	cellular anatomical entity	None	Extended
CC	GO:0120025	plasma membrane bounded cell projection	None	Extended
BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	None	Extended
BP	GO:0120036	plasma membrane bounded cell projection organization	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:0140253	cell-cell fusion	None	Extended
MF	GO:0140297	DNA-binding transcription factor binding	None	Extended
CC	GO:0140535	intracellular protein-containing complex	None	Extended
BP	GO:0150101	regulation of microtubule anchoring at centrosome	IEA	AHRD
BP	GO:1900180	regulation of protein localization to nucleus	None	Extended
BP	GO:1900181	negative regulation of protein localization to nucleus	IEA	AHRD
BP	GO:1900271	regulation of long-term synaptic potentiation	IEA	AHRD
BP	GO:1900457	regulation of brassinosteroid mediated signaling pathway	None	Extended
BP	GO:1900458	negative regulation of brassinosteroid mediated signaling pathway	IEA	AHRD
BP	GO:1901000	regulation of response to salt stress	None	Extended
BP	GO:1901002	positive regulation of response to salt stress	IEA	AHRD
BP	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	None	Extended
BP	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IEA	AHRD
BP	GO:1901214	regulation of neuron death	None	Extended
BP	GO:1901215	negative regulation of neuron death	IEA	AHRD
BP	GO:1901216	positive regulation of neuron death	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901652	response to peptide	None	Extended
BP	GO:1901653	cellular response to peptide	None	Extended
BP	GO:1901698	response to nitrogen compound	None	Extended
BP	GO:1901699	cellular response to nitrogen compound	None	Extended
BP	GO:1901700	response to oxygen-containing compound	None	Extended
BP	GO:1901701	cellular response to oxygen-containing compound	None	Extended
BP	GO:1901800	positive regulation of proteasomal protein catabolic process	None	Extended
BP	GO:1901888	regulation of cell junction assembly	None	Extended
BP	GO:1901889	negative regulation of cell junction assembly	None	Extended
BP	GO:1901890	positive regulation of cell junction assembly	None	Extended
BP	GO:1901983	regulation of protein acetylation	None	Extended
BP	GO:1901984	negative regulation of protein acetylation	IEA	AHRD
BP	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	None	Extended
BP	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA	AHRD
BP	GO:1902105	regulation of leukocyte differentiation	None	Extended
BP	GO:1902107	positive regulation of leukocyte differentiation	None	Extended
BP	GO:1902473	regulation of protein localization to synapse	None	Extended
CC	GO:1902494	catalytic complex	None	Extended
BP	GO:1902531	regulation of intracellular signal transduction	None	Extended
BP	GO:1902532	negative regulation of intracellular signal transduction	None	Extended
BP	GO:1902679	negative regulation of RNA biosynthetic process	None	Extended
BP	GO:1902680	positive regulation of RNA biosynthetic process	None	Extended
BP	GO:1902683	regulation of receptor localization to synapse	None	Extended
CC	GO:1902911	protein kinase complex	IEA	AHRD
BP	GO:1903050	regulation of proteolysis involved in protein catabolic process	None	Extended
BP	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	None	Extended
BP	GO:1903305	regulation of regulated secretory pathway	None	Extended
BP	GO:1903429	regulation of cell maturation	None	Extended
BP	GO:1903430	negative regulation of cell maturation	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	None	Extended
BP	GO:1903508	positive regulation of nucleic acid-templated transcription	None	Extended
BP	GO:1903530	regulation of secretion by cell	None	Extended
BP	GO:1903706	regulation of hemopoiesis	None	Extended
BP	GO:1903708	positive regulation of hemopoiesis	None	Extended
BP	GO:1903828	negative regulation of protein localization	None	Extended
BP	GO:1903829	positive regulation of protein localization	None	Extended
BP	GO:1904019	epithelial cell apoptotic process	None	Extended
BP	GO:1904338	regulation of dopaminergic neuron differentiation	None	Extended
BP	GO:1904339	negative regulation of dopaminergic neuron differentiation	IEA	AHRD
BP	GO:1904375	regulation of protein localization to cell periphery	None	Extended
BP	GO:1904396	regulation of neuromuscular junction development	None	Extended
BP	GO:1904397	negative regulation of neuromuscular junction development	None	Extended
BP	GO:1904398	positive regulation of neuromuscular junction development	None	Extended
BP	GO:1904645	response to amyloid-beta	None	Extended
BP	GO:1904646	cellular response to amyloid-beta	IEA	AHRD
BP	GO:1904779	regulation of protein localization to centrosome	None	Extended
BP	GO:1904780	negative regulation of protein localization to centrosome	IEA	AHRD
BP	GO:1904781	positive regulation of protein localization to centrosome	IEA	AHRD
BP	GO:1904951	positive regulation of establishment of protein localization	None	Extended
BP	GO:1905207	regulation of cardiocyte differentiation	None	Extended
BP	GO:1905209	positive regulation of cardiocyte differentiation	None	Extended
BP	GO:1905244	regulation of modification of synaptic structure	None	Extended
BP	GO:1905392	plant organ morphogenesis	None	Extended
BP	GO:1905475	regulation of protein localization to membrane	None	Extended
BP	GO:1905710	positive regulation of membrane permeability	None	Extended
BP	GO:1905809	negative regulation of synapse organization	None	Extended
CC	GO:1990234	transferase complex	None	Extended
CC	GO:1990904	ribonucleoprotein complex	IEA	AHRD
CC	GO:1990909	Wnt signalosome	IEA	AHRD
BP	GO:2000026	regulation of multicellular organismal development	None	Extended
BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	None	Extended
BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	None	Extended
BP	GO:2000145	regulation of cell motility	None	Extended
BP	GO:2000146	negative regulation of cell motility	None	Extended
BP	GO:2000171	negative regulation of dendrite development	IEA	AHRD
BP	GO:2000278	regulation of DNA biosynthetic process	None	Extended
BP	GO:2000300	regulation of synaptic vesicle exocytosis	IEA	AHRD
BP	GO:2000463	positive regulation of excitatory postsynaptic potential	IEA	AHRD
BP	GO:2000573	positive regulation of DNA biosynthetic process	IEA	AHRD
BP	GO:2000725	regulation of cardiac muscle cell differentiation	None	Extended
BP	GO:2000727	positive regulation of cardiac muscle cell differentiation	IEA	AHRD
BP	GO:2000736	regulation of stem cell differentiation	None	Extended
BP	GO:2000738	positive regulation of stem cell differentiation	IEA	AHRD
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended
BP	GO:2001222	regulation of neuron migration	None	Extended
BP	GO:2001223	negative regulation of neuron migration	IEA	AHRD
BP	GO:2001233	regulation of apoptotic signaling pathway	None	Extended
BP	GO:2001234	negative regulation of apoptotic signaling pathway	None	Extended
BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	None	Extended
BP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000001	mitochondrion inheritance	IEP	Predict GO terms from Neighborhoods
MF	GO:0000030	mannosyltransferase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0000033	alpha-1,3-mannosyltransferase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0000045	autophagosome assembly	IEP	Predict GO terms from Neighborhoods
CC	GO:0000322	storage vacuole	IEP	Predict GO terms from Neighborhoods
CC	GO:0000326	protein storage vacuole	IEP	Predict GO terms from Neighborhoods
CC	GO:0000331	contractile vacuole	IEP	Predict GO terms from Neighborhoods
MF	GO:0000339	RNA cap binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0000340	RNA 7-methylguanosine cap binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0000494	box C/D RNA 3'-end processing	IEP	Predict GO terms from Neighborhoods
CC	GO:0000502	proteasome complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0001510	RNA methylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0001910	regulation of leukocyte mediated cytotoxicity	IEP	Predict GO terms from Neighborhoods
BP	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	IEP	Predict GO terms from Neighborhoods
BP	GO:0001959	regulation of cytokine-mediated signaling pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:0001960	negative regulation of cytokine-mediated signaling pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:0002697	regulation of immune effector process	IEP	Predict GO terms from Neighborhoods
BP	GO:0002699	positive regulation of immune effector process	IEP	Predict GO terms from Neighborhoods
BP	GO:0002703	regulation of leukocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002705	positive regulation of leukocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002706	regulation of lymphocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002708	positive regulation of lymphocyte mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002715	regulation of natural killer cell mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002717	positive regulation of natural killer cell mediated immunity	IEP	Predict GO terms from Neighborhoods
BP	GO:0002791	regulation of peptide secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0002792	negative regulation of peptide secretion	IEP	Predict GO terms from Neighborhoods
MF	GO:0003730	mRNA 3'-UTR binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0004190	aspartic-type endopeptidase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004722	protein serine/threonine phosphatase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004843	cysteine-type deubiquitinase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0005049	nuclear export signal receptor activity	IEP	Predict GO terms from Neighborhoods
CC	GO:0005643	nuclear pore	IEP	Predict GO terms from Neighborhoods
CC	GO:0005765	lysosomal membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0005789	endoplasmic reticulum membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0006275	regulation of DNA replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0006446	regulation of translational initiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0006486	protein glycosylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0006611	protein export from nucleus	IEP	Predict GO terms from Neighborhoods
BP	GO:0006629	lipid metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0006655	phosphatidylglycerol biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0006810	transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006884	cell volume homeostasis	IEP	Predict GO terms from Neighborhoods
BP	GO:0006886	intracellular protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006895	Golgi to endosome transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006896	Golgi to vacuole transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006898	receptor-mediated endocytosis	IEP	Predict GO terms from Neighborhoods
BP	GO:0006913	nucleocytoplasmic transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0006971	hypotonic response	IEP	Predict GO terms from Neighborhoods
BP	GO:0007140	male meiotic nuclear division	IEP	Predict GO terms from Neighborhoods
BP	GO:0007267	cell-cell signaling	IEP	Predict GO terms from Neighborhoods
BP	GO:0007268	chemical synaptic transmission	IEP	Predict GO terms from Neighborhoods
MF	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0008190	eukaryotic initiation factor 4E binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0008233	peptidase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0008494	translation activator activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0008962	phosphatidylglycerophosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0009895	negative regulation of catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0009992	cellular water homeostasis	IEP	Predict GO terms from Neighborhoods
BP	GO:0010712	regulation of collagen metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0010714	positive regulation of collagen metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:0010950	positive regulation of endopeptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0010952	positive regulation of peptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0015031	protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0016073	snRNA metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0016074	sno(s)RNA metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0016239	positive regulation of macroautophagy	IEP	Predict GO terms from Neighborhoods
BP	GO:0016241	regulation of macroautophagy	IEP	Predict GO terms from Neighborhoods
BP	GO:0016482	cytosolic transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0016579	protein deubiquitination	IEP	Predict GO terms from Neighborhoods
MF	GO:0016757	glycosyltransferase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0016758	hexosyltransferase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0017022	myosin binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0017069	snRNA binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0017070	U6 snRNA binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0019783	ubiquitin-like protein peptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0030104	water homeostasis	IEP	Predict GO terms from Neighborhoods
CC	GO:0030119	AP-type membrane coat adaptor complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0030121	AP-1 adaptor complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0030122	AP-2 adaptor complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0030131	clathrin adaptor complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0030141	secretory granule	IEP	Predict GO terms from Neighborhoods
MF	GO:0030276	clathrin binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0030414	peptidase inhibitor activity	IEP	Predict GO terms from Neighborhoods
CC	GO:0030532	small nuclear ribonucleoprotein complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0031123	RNA 3'-end processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0031126	sno(s)RNA 3'-end processing	IEP	Predict GO terms from Neighborhoods
MF	GO:0031267	small GTPase binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0031304	intrinsic component of mitochondrial inner membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0031305	integral component of mitochondrial inner membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0031312	extrinsic component of organelle membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0031315	extrinsic component of mitochondrial outer membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0031330	negative regulation of cellular catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0031341	regulation of cell killing	IEP	Predict GO terms from Neighborhoods
BP	GO:0031343	positive regulation of cell killing	IEP	Predict GO terms from Neighborhoods
MF	GO:0031369	translation initiation factor binding	IEP	Predict GO terms from Neighborhoods
CC	GO:0031410	cytoplasmic vesicle	IEP	Predict GO terms from Neighborhoods
BP	GO:0031929	TOR signaling	IEP	Predict GO terms from Neighborhoods
CC	GO:0031982	vesicle	IEP	Predict GO terms from Neighborhoods
CC	GO:0032009	early phagosome	IEP	Predict GO terms from Neighborhoods
BP	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0032438	melanosome organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0032456	endocytic recycling	IEP	Predict GO terms from Neighborhoods
CC	GO:0032592	integral component of mitochondrial membrane	IEP	Predict GO terms from Neighborhoods
BP	GO:0032897	negative regulation of viral transcription	IEP	Predict GO terms from Neighborhoods
BP	GO:0032965	regulation of collagen biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0032967	positive regulation of collagen biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0033967	box C/D RNA metabolic process	IEP	Predict GO terms from Neighborhoods
MF	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0034963	box C/D RNA processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0035002	liquid clearance, open tracheal system	IEP	Predict GO terms from Neighborhoods
BP	GO:0035561	regulation of chromatin binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0035562	negative regulation of chromatin binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0035613	RNA stem-loop binding	IEP	Predict GO terms from Neighborhoods
MF	GO:0035615	clathrin adaptor activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0035646	endosome to melanosome transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0036093	germ cell proliferation	IEP	Predict GO terms from Neighborhoods
BP	GO:0038202	TORC1 signaling	IEP	Predict GO terms from Neighborhoods
BP	GO:0040031	snRNA modification	IEP	Predict GO terms from Neighborhoods
BP	GO:0042044	fluid transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0042045	epithelial fluid transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0042157	lipoprotein metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0042159	lipoprotein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0042177	negative regulation of protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0042269	regulation of natural killer cell mediated cytotoxicity	IEP	Predict GO terms from Neighborhoods
MF	GO:0043024	ribosomal small subunit binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0043144	sno(s)RNA processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0043413	macromolecule glycosylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0043485	endosome to pigment granule transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0043489	RNA stabilization	IEP	Predict GO terms from Neighborhoods
BP	GO:0043628	small regulatory ncRNA 3'-end processing	IEP	Predict GO terms from Neighborhoods
BP	GO:0044255	cellular lipid metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0045069	regulation of viral genome replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0045070	positive regulation of viral genome replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0045184	establishment of protein localization	IEP	Predict GO terms from Neighborhoods
CC	GO:0045335	phagocytic vesicle	IEP	Predict GO terms from Neighborhoods
BP	GO:0045472	response to ether	IEP	Predict GO terms from Neighborhoods
BP	GO:0045740	positive regulation of DNA replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0045947	negative regulation of translational initiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0045948	positive regulation of translational initiation	IEP	Predict GO terms from Neighborhoods
BP	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IEP	Predict GO terms from Neighborhoods
BP	GO:0046471	phosphatidylglycerol metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0046474	glycerophospholipid biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:0046676	negative regulation of insulin secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0046782	regulation of viral transcription	IEP	Predict GO terms from Neighborhoods
BP	GO:0046883	regulation of hormone secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0046888	negative regulation of hormone secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0046907	intracellular transport	IEP	Predict GO terms from Neighborhoods
MF	GO:0048027	mRNA 5'-UTR binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0048255	mRNA stabilization	IEP	Predict GO terms from Neighborhoods
BP	GO:0048308	organelle inheritance	IEP	Predict GO terms from Neighborhoods
BP	GO:0048311	mitochondrion distribution	IEP	Predict GO terms from Neighborhoods
BP	GO:0048524	positive regulation of viral process	IEP	Predict GO terms from Neighborhoods
BP	GO:0048525	negative regulation of viral process	IEP	Predict GO terms from Neighborhoods
BP	GO:0048753	pigment granule organization	IEP	Predict GO terms from Neighborhoods
BP	GO:0050708	regulation of protein secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0050709	negative regulation of protein secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0050792	regulation of viral process	IEP	Predict GO terms from Neighborhoods
BP	GO:0050796	regulation of insulin secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0050920	regulation of chemotaxis	IEP	Predict GO terms from Neighborhoods
MF	GO:0051020	GTPase binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0051048	negative regulation of secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0051168	nuclear export	IEP	Predict GO terms from Neighborhoods
BP	GO:0051169	nuclear transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051224	negative regulation of protein transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0051234	establishment of localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051646	mitochondrion localization	IEP	Predict GO terms from Neighborhoods
BP	GO:0051649	establishment of localization in cell	IEP	Predict GO terms from Neighborhoods
MF	GO:0052866	phosphatidylinositol phosphate phosphatase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0060759	regulation of response to cytokine stimulus	IEP	Predict GO terms from Neighborhoods
BP	GO:0060761	negative regulation of response to cytokine stimulus	IEP	Predict GO terms from Neighborhoods
MF	GO:0061135	endopeptidase regulator activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IEP	Predict GO terms from Neighborhoods
BP	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	IEP	Predict GO terms from Neighborhoods
BP	GO:0061951	establishment of protein localization to plasma membrane	IEP	Predict GO terms from Neighborhoods
MF	GO:0070001	aspartic-type peptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0070085	glycosylation	IEP	Predict GO terms from Neighborhoods
BP	GO:0070265	necrotic cell death	IEP	Predict GO terms from Neighborhoods
MF	GO:0070628	proteasome binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0070633	transepithelial transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0070646	protein modification by small protein removal	IEP	Predict GO terms from Neighborhoods
MF	GO:0070717	poly-purine tract binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0071362	cellular response to ether	IEP	Predict GO terms from Neighborhoods
BP	GO:0071702	organic substance transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0071705	nitrogen compound transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0072752	cellular response to rapamycin	IEP	Predict GO terms from Neighborhoods
BP	GO:0090087	regulation of peptide transport	IEP	Predict GO terms from Neighborhoods
BP	GO:0090276	regulation of peptide hormone secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0090278	negative regulation of peptide hormone secretion	IEP	Predict GO terms from Neighborhoods
BP	GO:0090296	regulation of mitochondrial DNA replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0090297	positive regulation of mitochondrial DNA replication	IEP	Predict GO terms from Neighborhoods
BP	GO:0090329	regulation of DNA-templated DNA replication	IEP	Predict GO terms from Neighborhoods
MF	GO:0097322	7SK snRNA binding	IEP	Predict GO terms from Neighborhoods
BP	GO:0097502	mannosylation	IEP	Predict GO terms from Neighborhoods
CC	GO:0097708	intracellular vesicle	IEP	Predict GO terms from Neighborhoods
CC	GO:0098573	intrinsic component of mitochondrial membrane	IEP	Predict GO terms from Neighborhoods
CC	GO:0098797	plasma membrane protein complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0098916	anterograde trans-synaptic signaling	IEP	Predict GO terms from Neighborhoods
BP	GO:0099536	synaptic signaling	IEP	Predict GO terms from Neighborhoods
BP	GO:0099537	trans-synaptic signaling	IEP	Predict GO terms from Neighborhoods
BP	GO:0099638	endosome to plasma membrane protein transport	IEP	Predict GO terms from Neighborhoods
MF	GO:0101005	deubiquitinase activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:0106349	snRNA methylation	IEP	Predict GO terms from Neighborhoods
CC	GO:0120114	Sm-like protein family complex	IEP	Predict GO terms from Neighborhoods
CC	GO:0120259	7SK snRNP	IEP	Predict GO terms from Neighborhoods
BP	GO:0140013	meiotic nuclear division	IEP	Predict GO terms from Neighborhoods
MF	GO:0140104	molecular carrier activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0140142	nucleocytoplasmic carrier activity	IEP	Predict GO terms from Neighborhoods
MF	GO:0140312	cargo adaptor activity	IEP	Predict GO terms from Neighborhoods
CC	GO:0140513	nuclear protein-containing complex	IEP	Predict GO terms from Neighborhoods
BP	GO:0140747	regulation of ncRNA transcription	IEP	Predict GO terms from Neighborhoods
BP	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IEP	Predict GO terms from Neighborhoods
BP	GO:1900182	positive regulation of protein localization to nucleus	IEP	Predict GO terms from Neighborhoods
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1901355	response to rapamycin	IEP	Predict GO terms from Neighborhoods
BP	GO:1901655	cellular response to ketone	IEP	Predict GO terms from Neighborhoods
BP	GO:1901799	negative regulation of proteasomal protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1901858	regulation of mitochondrial DNA metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1901860	positive regulation of mitochondrial DNA metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	IEP	Predict GO terms from Neighborhoods
BP	GO:1902369	negative regulation of RNA catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1902373	negative regulation of mRNA catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1902415	regulation of mRNA binding	IEP	Predict GO terms from Neighborhoods
BP	GO:1902416	positive regulation of mRNA binding	IEP	Predict GO terms from Neighborhoods
BP	GO:1902806	regulation of cell cycle G1/S phase transition	IEP	Predict GO terms from Neighborhoods
BP	GO:1902808	positive regulation of cell cycle G1/S phase transition	IEP	Predict GO terms from Neighborhoods
BP	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1903069	regulation of ER-associated ubiquitin-dependent protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1903312	negative regulation of mRNA metabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:1903531	negative regulation of secretion by cell	IEP	Predict GO terms from Neighborhoods
BP	GO:1903573	negative regulation of response to endoplasmic reticulum stress	IEP	Predict GO terms from Neighborhoods
BP	GO:1903900	regulation of viral life cycle	IEP	Predict GO terms from Neighborhoods
BP	GO:1904292	regulation of ERAD pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:1904293	negative regulation of ERAD pathway	IEP	Predict GO terms from Neighborhoods
BP	GO:1904869	regulation of protein localization to Cajal body	IEP	Predict GO terms from Neighborhoods
BP	GO:1904871	positive regulation of protein localization to Cajal body	IEP	Predict GO terms from Neighborhoods
BP	GO:1904950	negative regulation of establishment of protein localization	IEP	Predict GO terms from Neighborhoods
BP	GO:1905037	autophagosome organization	IEP	Predict GO terms from Neighborhoods
BP	GO:1905214	regulation of RNA binding	IEP	Predict GO terms from Neighborhoods
BP	GO:1905216	positive regulation of RNA binding	IEP	Predict GO terms from Neighborhoods
CC	GO:1905368	peptidase complex	IEP	Predict GO terms from Neighborhoods
CC	GO:1905369	endopeptidase complex	IEP	Predict GO terms from Neighborhoods
BP	GO:1905380	regulation of snRNA transcription by RNA polymerase II	IEP	Predict GO terms from Neighborhoods
BP	GO:1905382	positive regulation of snRNA transcription by RNA polymerase II	IEP	Predict GO terms from Neighborhoods
BP	GO:1905897	regulation of response to endoplasmic reticulum stress	IEP	Predict GO terms from Neighborhoods
BP	GO:1990437	snRNA 2'-O-methylation	IEP	Predict GO terms from Neighborhoods
BP	GO:1990438	U6 2'-O-snRNA methylation	IEP	Predict GO terms from Neighborhoods
MF	GO:1990825	sequence-specific mRNA binding	IEP	Predict GO terms from Neighborhoods
BP	GO:1990928	response to amino acid starvation	IEP	Predict GO terms from Neighborhoods
BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	IEP	Predict GO terms from Neighborhoods
BP	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IEP	Predict GO terms from Neighborhoods
BP	GO:2000105	positive regulation of DNA-templated DNA replication	IEP	Predict GO terms from Neighborhoods
BP	GO:2000116	regulation of cysteine-type endopeptidase activity	IEP	Predict GO terms from Neighborhoods
BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	IEP	Predict GO terms from Neighborhoods

InterPro domains	Description	Start	Stop
IPR011009	Kinase-like_dom_sf	74	384
IPR000719	Prot_kinase_dom	75	358

External Links

No external refs found!

SOLTUB.AGRIA.G00000040441

Expression Profile

Co-expression Networks

Functional Annotation